{"metadata":{"accession":"PF10995","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR063588","hierarchy":null,"name":{"name":"Cellulose biosynthesis protein BcsE, N-terminal domain","short":"BcsE_N"},"description":[{"text":"<p>This entry includes members involved in cellulose biosynthesis such as BcsE proteins found in Salmonella typhimurium. They consist of a N-terminal NTPase catalytically incompetent nucleoside triphosphatase domain followed by a REC (phosphorylation-incompetent receiver domain) and a C-terminal GGDEF (degenerate diguanylate cyclase domain). The REC and GGDEF domains were firstly described as the GIL domain [[cite:PUB00100649],[cite:PUB00163548]]. BcsE proteins are not essential for cellulose synthesis but is critical for maximal cellulose production. Cellulose production in enterobacteria is controlled by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase BcsA [[cite:PUB00086880],[cite:PUB00075887],[cite:PUB00100649],[cite:PUB00100650],[cite:PUB00100648]]. This domain forms a membrane-proximal head-to-head dimer of P-loop nucleotide NTPase-like modules [[cite:PUB00163548]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100648":{"PMID":33712813,"ISBN":null,"volume":"28","issue":"3","year":2021,"title":"Molecular organization of the E. coli cellulose synthase macrocomplex.","URL":null,"raw_pages":"310-318","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat Struct Mol Biol","authors":["Acheson JF","Ho R","Goularte NF","Cegelski L","Zimmer J."],"DOI_URL":null},"PUB00163548":{"PMID":39394223,"ISBN":null,"volume":"15","issue":"1","year":2024,"title":"Structural basis for synthase activation and cellulose modification in the E. coli Type II Bcs secretion system.","URL":null,"raw_pages":"8799","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Anso I","Zouhir S","Sana TG","Krasteva PV."],"DOI_URL":"https://doi.org/10.1038/s41467-024-53113-8"},"PUB00100650":{"PMID":29348238,"ISBN":null,"volume":"359","issue":"6373","year":2018,"title":"Phosphoethanolamine cellulose: A naturally produced chemically modified cellulose.","URL":null,"raw_pages":"334-338","medline_journal":"Science","ISO_journal":"Science","authors":["Thongsomboon W","Serra DO","Possling A","Hadjineophytou C","Hengge R","Cegelski L."],"DOI_URL":null},"PUB00075887":{"PMID":26077867,"ISBN":null,"volume":null,"issue":null,"year":2015,"title":"Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions.","URL":null,"raw_pages":null,"medline_journal":"Trends Microbiol","ISO_journal":"Trends Microbiol.","authors":["Romling U","Galperin MY."],"DOI_URL":"http://dx.doi.org/10.1016/j.tim.2015.05.005"},"PUB00100649":{"PMID":32788377,"ISBN":null,"volume":"11","issue":"4","year":2020,"title":"Structure and Multitasking of the c-di-GMP-Sensing Cellulose Secretion Regulator BcsE.","URL":null,"raw_pages":null,"medline_journal":"mBio","ISO_journal":"mBio","authors":["Zouhir S","Abidi W","Caleechurn M","Krasteva PV."],"DOI_URL":null},"PUB00086880":{"PMID":24942809,"ISBN":null,"volume":"93","issue":"3","year":2014,"title":"GIL, a new c-di-GMP-binding protein domain involved in regulation of cellulose synthesis in enterobacteria.","URL":null,"raw_pages":"439-52","medline_journal":"Mol Microbiol","ISO_journal":"Mol. Microbiol.","authors":["Fang X","Ahmad I","Blanka A","Schottkowski M","Cimdins A","Galperin MY","Romling U","Gomelsky M."],"DOI_URL":"https://doi.org/10.1111/mmi.12672"}},"set_info":{"accession":"CL0023","name":"P-loop_NTPase"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":605,"pathways":0,"proteins":604,"proteomes":594,"sets":1,"structural_models":{"alphafold":326},"structures":4,"taxa":869},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":22,"alignment:full":169},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}