{"metadata":{"accession":"PF10980","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021248","hierarchy":null,"name":{"name":"Protein of unknown function (DUF2787)","short":"DUF2787"},"description":[{"text":"<p>This bacterial family of proteins has no known function. The conserved hypothetical protein VC1805 from Vibrio cholerae belongs to this group. It adopts a monomeric assembly, showing an unusual topology with a flat seven-stranded anti-parallel beta-sheet and two helices located on the same side of the sheet. It has some structural homology with the human protein p32 and binds to the complement protein C1q, which suggests a possible role in the adherence of the bacteria to the intestinal wall [[cite:PUB00049533]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00049533":{"PMID":18300248,"ISBN":null,"volume":"71","issue":"3","year":2008,"title":"Crystal structure of VC1805, a conserved hypothetical protein from a Vibrio cholerae pathogenicity island, reveals homology to human p32.","URL":null,"raw_pages":"1563-71","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Sheikh MA","Potter JA","Johnson KA","Sim RB","Boyd EF","Taylor GL."],"DOI_URL":"http://dx.doi.org/10.1002/prot.21993"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":505,"pathways":0,"proteins":505,"proteomes":259,"sets":0,"structural_models":{"alphafold":289},"structures":2,"taxa":433},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":134},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2w56","name":"Structure of the hypothetical protein VC0508 from Vibrio cholerae VSP- II pathogenicity island"}}}