{"metadata":{"accession":"PF10961","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024491","hierarchy":null,"name":{"name":"Selenoprotein SelK_SelG","short":"SelK_SelG"},"description":[{"text":"<p>This entry inclues a group of eukaryotic selenoproteins,  such as SelK and SelG. SelK seems to play an important  role in protecting cells from endoplasmic reticulum  stress induced apoptosis [[cite:PUB00056137]]. SelG may be involved in  regulating the redox state of the cell [[cite:PUB00056138]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00056138":{"PMID":11389138,"ISBN":null,"volume":"276","issue":"32","year":2001,"title":"Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality.","URL":null,"raw_pages":"29798-804","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Martin-Romero FJ","Kryukov GV","Lobanov AV","Carlson BA","Lee BJ","Gladyshev VN","Hatfield DL."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M100422200"},"PUB00056137":{"PMID":20692228,"ISBN":null,"volume":"502","issue":"2","year":2010,"title":"SelK is a novel ER stress-regulated protein and protects HepG2 cells from ER stress agent-induced apoptosis.","URL":null,"raw_pages":"137-43","medline_journal":"Arch Biochem Biophys","ISO_journal":"Arch. Biochem. Biophys.","authors":["Du S","Zhou J","Jia Y","Huang K."],"DOI_URL":"http://dx.doi.org/10.1016/j.abb.2010.08.001"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":2014,"pathways":0,"proteins":2011,"proteomes":1603,"sets":0,"structural_models":{"alphafold":1697},"structures":0,"taxa":5148},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":31,"alignment:full":1479},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}