{"metadata":{"accession":"PF10945","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024487","hierarchy":null,"name":{"name":"Cellulose biosynthesis protein BcsR-like","short":"CBP_BcsR"},"description":[{"text":"<p>Cellulose is necessary for biofilm formation in bacteria and is synthesized by the bacterial cellulose biosynthesis complex (Bcs) which is widespread among beta and gamma proteobacteria [[cite:PUB00075887],[cite:PUB00105928]]. CBP_BcsR is a small subunit of this complex, essential for cellulose secretion [[cite:PUB00105928]]. It may play a regulatory role together with BcsQ subunit as they form a subcomplex with chaperone-like function toward each other [[cite:PUB00151583]]. BcsR stabilizes BcsQ to form monodisperse BcsR2Q2 heterotetramers in solution and BcsQ may play a role in the folding and subsequent stability of BcsR [[cite:PUB00151583]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00105928":{"PMID":29234007,"ISBN":null,"volume":"8","issue":"1","year":2017,"title":"Insights into the structure and assembly of a bacterial cellulose secretion system.","URL":null,"raw_pages":"2065","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Krasteva PV","Bernal-Bayard J","Travier L","Martin FA","Kaminski PA","Karimova G","Fronzes R","Ghigo JM."],"DOI_URL":null},"PUB00075887":{"PMID":26077867,"ISBN":null,"volume":null,"issue":null,"year":2015,"title":"Bacterial cellulose biosynthesis: diversity of operons, subunits, products, and functions.","URL":null,"raw_pages":null,"medline_journal":"Trends Microbiol","ISO_journal":"Trends Microbiol.","authors":["Romling U","Galperin MY."],"DOI_URL":"http://dx.doi.org/10.1016/j.tim.2015.05.005"},"PUB00151583":{"PMID":33563593,"ISBN":null,"volume":"7","issue":"5","year":2021,"title":"Architecture and regulation of an enterobacterial cellulose secretion system. ","URL":null,"raw_pages":"eabd8049","medline_journal":"Sci Adv","ISO_journal":"Sci Adv","authors":["Abidi W","Zouhir S","Caleechurn M","Roche S","Krasteva PV."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":624,"pathways":0,"proteins":624,"proteomes":606,"sets":0,"structural_models":{"alphafold":389},"structures":9,"taxa":847},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":16,"alignment:full":187},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6yb5","name":"Orthorhombic crystal structure of a native BcsRQ complex crystallized in the presence of ADP"}}}