{"metadata":{"accession":"PF10942","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR020390","hierarchy":null,"name":{"name":"Protein of unknown function (DUF2619)","short":"DUF2619"},"description":[{"text":"<p>This bacterial family of proteins has no known function. This family includes the B. subtilis YqhV protein which is found just upstream of the SpoIIIA operon, suggesting it may play a role in sporulation or its regulation [[cite:PUB00034563]]. The protein is composed of three hydrophobic alpha helices that may form transmembrane helices.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00034563":{"PMID":15383836,"ISBN":null,"volume":"2","issue":"10","year":2004,"title":"The program of gene transcription for a single differentiating cell type during sporulation in Bacillus subtilis.","URL":null,"raw_pages":"e328","medline_journal":"PLoS Biol","ISO_journal":"PLoS Biol.","authors":["Eichenberger P","Fujita M","Jensen ST","Conlon EM","Rudner DZ","Wang ST","Ferguson C","Haga K","Sato T","Liu JS","Losick R."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pbio.0020328"},"PUB00152806":{"PMID":17693505,"ISBN":null,"volume":"189","issue":"20","year":2007,"title":"Essential internal promoter in the spoIIIA locus of Bacillus subtilis.","URL":null,"raw_pages":"7181-9","medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Guillot C","Moran CP Jr."],"DOI_URL":"https://doi.org/10.1128/JB.00915-07"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":835,"pathways":0,"proteins":835,"proteomes":825,"sets":0,"structural_models":{"alphafold":523},"structures":0,"taxa":1101},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":47,"alignment:full":420},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}