{"metadata":{"accession":"PF10940","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR021237","hierarchy":null,"name":{"name":"Leader peptide SpeFL","short":"SpeFL"},"description":[{"text":"<p>SpeFL is a small protein (arrest peptide) encoded upstream of inducible ornithine carboxylase gene (speF) that controls expression of downstream genes (speF and patE) by nascent chain-translational arrest and transcriptional attenuation. Ornithine capture by a translating ribosome controls bacterial polyamine synthesis, inducing the expression of ornithine decarboxylase SpeF4, in a mechanism involving ribosome stalling and transcription antitermination [[cite:PUB00098030]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00098030":{"PMID":32094585,"ISBN":null,"volume":"5","issue":"4","year":2020,"title":"Ornithine capture by a translating ribosome controls bacterial polyamine synthesis.","URL":null,"raw_pages":"554-561","medline_journal":"Nat Microbiol","ISO_journal":"Nat Microbiol","authors":["Herrero Del Valle A","Seip B","Cervera-Marzal I","Sacheau G","Seefeldt AC","Innis CA."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":119,"pathways":0,"proteins":119,"proteomes":116,"sets":0,"structural_models":{"alphafold":62},"structures":0,"taxa":193},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":2,"alignment:full":18},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}