{"metadata":{"accession":"PF10934","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR020288","hierarchy":null,"name":{"name":"Contractile injection system sheath initiator","short":"Sheath_initiator"},"description":[{"text":"<p>This entry represents the sheath initiator protein found in contractile injection systems like diffocins, pyocins, and phage tail-like particles. The sheath initiator acts as an intermediate between the baseplate triplex and the first layer of the sheath, and between the tube tail and hub. It has a critical role in transmitting contraction signals from the baseplate wedge to the sheath through the N-terminal domain which binds to the core bundle of the triplex, while the C-terminal beta-hairpin interacts with two sheath proteins on the first layer by forming a conserved handshake interface. The N-terminal loops of adjacent sheath initiators adopt different conformations to accommodate the symmetry mismatch between the baseplate wedge and hub.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00160016":{"PMID":39152109,"ISBN":null,"volume":"15","issue":"1","year":2024,"title":"Atomic structures of a bacteriocin targeting Gram-positive bacteria.","URL":null,"raw_pages":"7057","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Cai X","He Y","Yu I","Imani A","Scholl D","Miller JF","Zhou ZH."],"DOI_URL":"https://doi.org/10.1038/s41467-024-51038-w"}},"set_info":{"accession":"CL0763","name":"GpW_gp25-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":7,"interactions":0,"matches":2400,"pathways":0,"proteins":2400,"proteomes":1845,"sets":1,"structural_models":{"alphafold":1129},"structures":26,"taxa":3585},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":83,"alignment:full":1130},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}