This domain found in archaeal proteins, including PF2050 from Pyrococcus furiosus ([swissprot:Q8TZE5]). PF2050, with an overall globular structure, contain this domain twice, each showing an antiparallel beta-sheet and an alpha-helical bundle, and shows a positively charged basic cleft on one side. This protein interacts with circular and linear dsDNA [[cite:PUB00100885]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00100885":{"PMID":22616997,"ISBN":null,"volume":"586","issue":"9","year":2012,"title":"Crystal structure of Pyrococcus furiosus PF2050, a member of the DUF2666 protein family.","URL":null,"raw_pages":"1384-8","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett","authors":["Han BG","Jeong KC","Cho JW","Jeong BC","Song HK","Lee JY","Shin DH","Lee S","Lee BI."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3,"interactions":0,"matches":85,"pathways":0,"proteins":54,"proteomes":54,"sets":0,"structural_models":{"alphafold":52},"structures":1,"taxa":113},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":19},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3v68","name":"Crystal structure of Pyrococcus furiosus PF2050, a member of DUF2666 family protein"}}}