{"metadata":{"accession":"PF10862","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR022598","hierarchy":null,"name":{"name":"FcoT-like thioesterase domain","short":"FcoT"},"description":[{"text":"<p>Proteins in this family have a HotDog fold. This family was formerly known as domain of unknown function 2662 (DUF2662). The structure of Rv0098 from M. tuberculosis [[cite:PUB00048671]] suggested a thioesterase function. Assays showed that this protein was a thioesterase with a preference for long chain fatty acyl groups [[cite:PUB00048671]]. The maximal Kcat was observed for palmitoyl-CoA although longer and shorter molecules were also cleaved. In solution this protein forms a homo-hexameric complex.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00048671":{"PMID":17524985,"ISBN":null,"volume":"14","issue":"5","year":2007,"title":"Identification of a type III thioesterase reveals the function of an operon crucial for Mtb virulence.","URL":null,"raw_pages":"543-51","medline_journal":"Chem Biol","ISO_journal":"Chem. Biol.","authors":["Wang F","Langley R","Gulten G","Wang L","Sacchettini JC."],"DOI_URL":"http://dx.doi.org/10.1016/j.chembiol.2007.04.005"}},"set_info":{"accession":"CL0050","name":"HotDog"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":298,"pathways":0,"proteins":298,"proteomes":264,"sets":1,"structural_models":{"alphafold":186},"structures":4,"taxa":450},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":142},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"5wsy","name":"The complex structure of SAV606 with N-carboxymethyl-3-aminobutyrate"}}}