{"metadata":{"accession":"PF10818","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR020508","hierarchy":null,"name":{"name":"secA translation cis-regulator SecM, small type","short":"SecM_small"},"description":[{"text":"<p>In E. coli, SecM encodes a presecretory protein that regulates secA expression at the translational level. SecM contains a C-terminal sequence motif that induces a transient translation arrest [[cite:PUB00097606]]. SecM signal peptide plays an essential role in this regulatory process by acting as a molecular timer that coordinates secM membrane targeting with the synthesis of the arrest motif [[cite:PUB00097606]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00097606":{"PMID":21635582,"ISBN":null,"volume":"81","issue":"2","year":2011,"title":"The translational regulatory function of SecM requires the precise timing of membrane targeting.","URL":null,"raw_pages":"540-53","medline_journal":"Mol Microbiol","ISO_journal":"Mol Microbiol","authors":["Yap MN","Bernstein HD."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":100,"pathways":0,"proteins":100,"proteomes":100,"sets":0,"structural_models":{"alphafold":70},"structures":0,"taxa":162},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":36},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}