This family of proteins includes the uncharacterized protein MJ0366 from Methanocaldococcus jannaschii and similar proteins predominantly found in Methanococci. This protein adopts the 3-1 trefoil knot conformation [[cite:PUB00100668]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00100668":{"PMID":27845039,"ISBN":null,"volume":"482","issue":"2","year":2017,"title":"Crystal structure analysis of a hypothetical protein (MJ0366) from Methanocaldococcus jannaschii revealed a novel topological arrangement of the knot fold.","URL":null,"raw_pages":"264-269","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem Biophys Res Commun","authors":["Thiruselvam V","Kumarevel T","Karthe P","Kuramitsu S","Yokoyama S","Ponnuswamy MN."],"DOI_URL":null}},"set_info":{"accession":"CL0057","name":"Met_repress"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":15,"pathways":0,"proteins":15,"proteomes":10,"sets":1,"structural_models":{"alphafold":12},"structures":1,"taxa":42},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":4,"alignment:full":6},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2efv","name":"Crystal Structure of a Hypothetical Protein(MJ0366) from Methanocaldococcus jannaschii"}}}