This family is conserved in bacteria and archaea. The function is not known. The structure of two proteins in this family were solved using NMR and shown to adopt a winged helix-turn-helix fold [[cite:PUB00075673]]. Structural analysis shows that these proteins form an unusual dimeric conformation. This dimer was shown to be similar to that found in the FadR and TubR wHTH domains. It was suggested [[cite:PUB00075673]] that these proteins are not very likely to bind to DNA.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00075673":{"PMID":22223187,"ISBN":null,"volume":"13","issue":"1","year":2012,"title":"Solution NMR structures reveal unique homodimer formation by a winged helix-turn-helix motif and provide first structures for protein domain family PF10771.","URL":null,"raw_pages":"1-7","medline_journal":"J Struct Funct Genomics","ISO_journal":"J. Struct. Funct. Genomics","authors":["Eletsky A","Petrey D","Zhang QC","Lee HW","Acton TB","Xiao R","Everett JK","Prestegard JH","Honig B","Montelione GT","Szyperski T."],"DOI_URL":"http://dx.doi.org/10.1007/s10969-011-9121-3"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":575,"pathways":0,"proteins":575,"proteomes":323,"sets":1,"structural_models":{"alphafold":404},"structures":2,"taxa":576},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":14,"alignment:full":365},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}