{"metadata":{"accession":"PF10753","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019689","hierarchy":null,"name":{"name":"Toxin GhoT_OrtT","short":"Toxin_GhoT_OrtT"},"description":[{"text":"<p>GhoT is part of the GhoT-GhoS type V toxin-antitoxin (TA) system [[cite:PUB00065335],[cite:PUB00074308]]. OrtT is homologous to GhoT, but it is not part of a TA pair. In this case, it acts as an independent toxin to reduce growth during stress related to amino acid and DNA synthesis [[cite:PUB00074307]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00074307":{"PMID":25643179,"ISBN":null,"volume":"7","issue":"2","year":2015,"title":"Orphan Toxin OrtT (YdcX) of Escherichia coli Reduces Growth during the Stringent Response.","URL":null,"raw_pages":"299-321","medline_journal":"Toxins (Basel)","ISO_journal":"Toxins (Basel)","authors":["Islam S","Benedik MJ","Wood TK."],"DOI_URL":"http://dx.doi.org/10.3390/toxins7020299"},"PUB00065335":{"PMID":22941047,"ISBN":null,"volume":"8","issue":"10","year":2012,"title":"A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS.","URL":null,"raw_pages":"855-61","medline_journal":"Nat Chem Biol","ISO_journal":"Nat. Chem. Biol.","authors":["Wang X","Lord DM","Cheng HY","Osbourne DO","Hong SH","Sanchez-Torres V","Quiroga C","Zheng K","Herrmann T","Peti W","Benedik MJ","Page R","Wood TK."],"DOI_URL":"http://dx.doi.org/10.1038/nchembio.1062"},"PUB00074308":{"PMID":23289863,"ISBN":null,"volume":"15","issue":"6","year":2013,"title":"Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS.","URL":null,"raw_pages":"1734-44","medline_journal":"Environ Microbiol","ISO_journal":"Environ. Microbiol.","authors":["Wang X","Lord DM","Hong SH","Peti W","Benedik MJ","Page R","Wood TK."],"DOI_URL":"http://dx.doi.org/10.1111/1462-2920.12063"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":1,"interactions":0,"matches":370,"pathways":0,"proteins":370,"proteomes":339,"sets":0,"structural_models":{"alphafold":226},"structures":0,"taxa":502},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":36,"alignment:full":88},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}