{"metadata":{"accession":"PF10747","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019683","hierarchy":null,"name":{"name":"Sporulation inhibitor of replication protein SirA","short":"SirA"},"description":[{"text":"<p>This entry represents the Sporulation inhibitor of  replication (sirA) family of proteins from Bacillus sp.  Induction of sporulation in rapidly growing cells inhibits  replication; this is thought to be through the action of SirA protein and independent of phosphorylated Spo0A;  however SirA protein synthesis is induced by Spo0A [[cite:PUB00054159]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00054159":{"PMID":19329632,"ISBN":null,"volume":"191","issue":"11","year":2009,"title":"The conserved sporulation protein YneE inhibits DNA replication in Bacillus subtilis.","URL":null,"raw_pages":"3736-9","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Rahn-Lee L","Gorbatyuk B","Skovgaard O","Losick R."],"DOI_URL":"http://dx.doi.org/10.1128/JB.00216-09"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":606,"pathways":0,"proteins":605,"proteomes":603,"sets":0,"structural_models":{"alphafold":360},"structures":1,"taxa":764},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":293},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"4tps","name":"Sporulation Inhibitor of DNA Replication, SirA, in complex with Domain I of DnaA"}}}