This domain is conserved in the Bacillales. The function is not known, but given this domain's relationship to the SIS domain it may carry out a sugar isomerase reaction. Several members are annotated as being YWJG, a protein expressed downstream of pyrG, a gene encoding for cytidine triphosphate synthetase.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0067","name":"SIS"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":667,"pathways":0,"proteins":666,"proteomes":664,"sets":1,"structural_models":{"alphafold":403},"structures":1,"taxa":849},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":278},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3jx9","name":"Crystal structure of Putative phosphoheptose isomerase (YP_001815198.1) from Exiguobacterium sp. 255-15 at 1.95 A resolution"}}}