{"metadata":{"accession":"PF10709","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019648","hierarchy":null,"name":{"name":"Protein YebY","short":"YebY"},"description":[{"text":"<p>This protein family includes Protein YebY from Escherichia coli and similar proteins predominantly found in Gammaproteobacteria. YebY is a component of the AZY copper uptake system, where it functions as a negative regulator of the copper importer YebZ [[cite:PUB00163268]]. At high copper concentrations, YebY may act as a safety valve, preventing toxic copper overload by inhibiting the import activity of YebZ and YobA [[cite:PUB00163268]]. The reduced form of YebY binds Cu(+) and Cu(2+) with low affinity and shows low specificity, also binding Co(2+), Ni(2+), and Ag(+) [[cite:PUB00100157]]. However, the low affinity of copper binding, together with the stabilisation imparted by a disulphide bond, suggests that this metal binding is likely not physiologically relevant [[cite:PUB00100157]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100157":{"PMID":34822841,"ISBN":null,"volume":null,"issue":null,"year":2021,"title":"The copper-linked E. coli AZY operon: Structure, metal binding, and a possible physiological role in copper delivery.","URL":null,"raw_pages":"101445","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Hadley RC","Zhitnitsky D","Livnat-Levanon N","Masrati G","Vigonsky E","Rose J","Ben-Tal N","Rosenzweig AC","Lewinson O."],"DOI_URL":null},"PUB00163268":{"PMID":40108346,"ISBN":null,"volume":"8","issue":"1","year":2025,"title":"The Escherichia coli AZY operon links copper uptake to antibiotic resistance.","URL":null,"raw_pages":"458","medline_journal":"Commun Biol","ISO_journal":"Commun Biol","authors":["Palmer CD","Ghnamah Y","Livnat-Levanon N","Lewinson O","Rosenzweig AC."],"DOI_URL":"https://doi.org/10.1038/s42003-025-07884-5"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":649,"pathways":0,"proteins":647,"proteomes":626,"sets":0,"structural_models":{"alphafold":385},"structures":3,"taxa":1011},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":5,"alignment:full":185},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7n0j","name":"Structure of YebY from E. coli K12"}}}