{"metadata":{"accession":"PF10629","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018902","hierarchy":null,"name":{"name":"Ciliary microtubule inner protein 2B-like","short":"CMI2B-like"},"description":[{"text":"<p>This family represents a domain found in human Ciliary microtubule inner protein 2B (CMI2B) and similar proteins from eukaryotes. CMI2B is a microtubule inner proteins (MIP) that form part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating [[cite:PUB00103594]]. This domain is a tubulin-binding domain. Some proteins contain multiple copies of this domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00103594":{"PMID":36191189,"ISBN":null,"volume":"119","issue":"41","year":2022,"title":"SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules.","URL":null,"raw_pages":"e2207605119","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Gui M","Croft JT","Zabeo D","Acharya V","Kollman JM","Burgoyne T","Hoog JL","Brown A."],"DOI_URL":null}},"set_info":{"accession":"CL0817","name":"SPMIP5_TBD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":30,"interactions":0,"matches":3198,"pathways":0,"proteins":2312,"proteomes":1030,"sets":1,"structural_models":{"alphafold":2008},"structures":16,"taxa":3462},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":24,"alignment:full":2458},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}