This domain is found in a group of putative heme-iron utilisation proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis [[cite:PUB00075508]]. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in heme and chlorophyll biosynthesis [[cite:PUB00075509]]. GluTRBP is necessary for efficient photosynthetic electron transport in chloroplasts [[cite:PUB00075510]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00075509":{"PMID":22180625,"ISBN":null,"volume":"23","issue":"12","year":2011,"title":"An Arabidopsis GluTR binding protein mediates spatial separation of 5-aminolevulinic acid synthesis in chloroplasts.","URL":null,"raw_pages":"4476-91","medline_journal":"Plant Cell","ISO_journal":"Plant Cell","authors":["Czarnecki O","Hedtke B","Melzer M","Rothbart M","Richter A","Schroter Y","Pfannschmidt T","Grimm B."],"DOI_URL":"http://dx.doi.org/10.1105/tpc.111.086421"},"PUB00075508":{"PMID":24753615,"ISBN":null,"volume":"111","issue":"18","year":2014,"title":"Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein.","URL":null,"raw_pages":"6630-5","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Zhao A","Fang Y","Chen X","Zhao S","Dong W","Lin Y","Gong W","Liu L."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1400166111"},"PUB00075510":{"PMID":20657737,"ISBN":null,"volume":"5","issue":"7","year":2010,"title":"Arabidopsis thaliana PGR7 encodes a conserved chloroplast protein that is necessary for efficient photosynthetic electron transport.","URL":null,"raw_pages":"e11688","medline_journal":"PLoS One","ISO_journal":"PLoS ONE","authors":["Jung HS","Okegawa Y","Shih PM","Kellogg E","Abdel-Ghany SE","Pilon M","Sjolander K","Shikanai T","Niyogi KK."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pone.0011688"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":76,"interactions":0,"matches":7613,"pathways":0,"proteins":7608,"proteomes":5685,"sets":0,"structural_models":{"alphafold":5075},"structures":16,"taxa":9310},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":166,"alignment:full":4274},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"8zxq","name":"Crystal structure of Ssr1698 in complex with heme b"}}}