{"metadata":{"accession":"PF10521","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018870","hierarchy":null,"name":{"name":"Tti2 family","short":"Tti2"},"description":[{"text":"<p>This family includes budding yeast Tel2-interacting protein 2 (Tti2) and similar proteins from animals and fungi. Tti2 is a component of the tel2-tti1-tti2 (TTT) complex, which is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Its homologue from humans, together with the TTT complex and HSP90, may participate in the proper folding of newly synthesised phosphatidylinositol 3-kinase-related protein kinase (PIKK) proteins [[cite:PUB00075571],[cite:PUB00073582],[cite:PUB00151832],[cite:PUB00088257]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00073582":{"PMID":20810650,"ISBN":null,"volume":"24","issue":"17","year":2010,"title":"A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.","URL":null,"raw_pages":"1939-50","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Hurov KE","Cotta-Ramusino C","Elledge SJ."],"DOI_URL":"http://dx.doi.org/10.1101/gad.1934210"},"PUB00151832":{"PMID":34233195,"ISBN":null,"volume":"36","issue":"1","year":2021,"title":"Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone.","URL":null,"raw_pages":"109317","medline_journal":"Cell Rep","ISO_journal":"Cell Rep","authors":["Pal M","Munoz-Hernandez H","Bjorklund D","Zhou L","Degliesposti G","Skehel JM","Hesketh EL","Thompson RF","Pearl LH","Llorca O","Prodromou C."],"DOI_URL":null},"PUB00075571":{"PMID":21552543,"ISBN":null,"volume":"7","issue":"4","year":2011,"title":"The complete spectrum of yeast chromosome instability genes identifies candidate CIN cancer genes and functional roles for ASTRA complex components.","URL":null,"raw_pages":"e1002057","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet.","authors":["Stirling PC","Bloom MS","Solanki-Patil T","Smith S","Sipahimalani P","Li Z","Kofoed M","Ben-Aroya S","Myung K","Hieter P."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pgen.1002057"},"PUB00088257":{"PMID":20801936,"ISBN":null,"volume":"24","issue":"18","year":2010,"title":"Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes.","URL":null,"raw_pages":"2019-30","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Takai H","Xie Y","de Lange T","Pavletich NP."],"DOI_URL":"https://doi.org/10.1101/gad.1956410"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":38,"interactions":0,"matches":2084,"pathways":0,"proteins":2074,"proteomes":1836,"sets":0,"structural_models":{"alphafold":1736},"structures":2,"taxa":4720},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":59,"alignment:full":1667},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}