{"metadata":{"accession":"PF10507","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019537","hierarchy":null,"name":{"name":"Transmembrane protein 65","short":"TMEM65"},"description":[{"text":"<p>MEM65 is an intercalated disc protein that interacts  with with connexin 43 (Cx43) and  is required for  correct localization of Cx43 to the intercalated disc. It is essential for cardiac function in zebrafish [[cite:PUB00078902]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00078902":{"PMID":26403541,"ISBN":null,"volume":"6","issue":null,"year":2015,"title":"Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.","URL":null,"raw_pages":"8391","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Sharma P","Abbasi C","Lazic S","Teng AC","Wang D","Dubois N","Ignatchenko V","Wong V","Liu J","Araki T","Tiburcy M","Ackerley C","Zimmermann WH","Hamilton R","Sun Y","Liu PP","Keller G","Stagljar I","Scott IC","Kislinger T","Gramolini AO."],"DOI_URL":"http://dx.doi.org/10.1038/ncomms9391"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":57,"interactions":0,"matches":2244,"pathways":0,"proteins":2227,"proteomes":1373,"sets":0,"structural_models":{"alphafold":1946},"structures":0,"taxa":4345},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":44,"alignment:full":1780},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}