{"metadata":{"accession":"PF10475","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019515","hierarchy":null,"name":{"name":"Vacuolar-sorting protein 54, of GARP complex","short":"Vps54_N"},"description":[{"text":"<p>This is a family of vacuolar-sorting proteins 54, from eukaryotes. Along with VPS52 and VPS53 this forms the Golgi-associated retrograde protein complex GARP [[cite:PUB00090044]]. VPS54 is separated into N- and C-terminal regions each of which has a different function. This N-terminal family of is important for GARP complex assembly and stability, whereas the C-terminal domain, [pfam:PF07928], brings about localisation to an early endocytic compartment [[cite:PUB00109230]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00090044":{"PMID":18367545,"ISBN":null,"volume":"19","issue":"6","year":2008,"title":"Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.","URL":null,"raw_pages":"2350-62","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Perez-Victoria FJ","Mardones GA","Bonifacino JS."],"DOI_URL":"https://doi.org/10.1091/mbc.e07-11-1189"},"PUB00109230":{"PMID":16452629,"ISBN":null,"volume":"17","issue":"4","year":2006,"title":"Domains within the GARP subunit Vps54 confer separate functions in complex assembly and early endosome recognition.","URL":null,"raw_pages":"1859-70","medline_journal":"Mol Biol Cell","ISO_journal":"Mol Biol Cell","authors":["Quenneville NR","Chao TY","McCaffery JM","Conibear E."],"DOI_URL":null}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":75,"interactions":0,"matches":5274,"pathways":0,"proteins":5144,"proteomes":2258,"sets":1,"structural_models":{"alphafold":4342},"structures":0,"taxa":6739},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":4104},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}