{"metadata":{"accession":"PF10474","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019514","hierarchy":null,"name":{"name":"Syndetin, C-terminal","short":"Syndetin_C"},"description":[{"text":"<p>The function of this domain is unknown but it is found at the C terminus of syndetin (VPS50), a unique component of the endosome-associated retrograde protein (EARP) complex. The EARP complex otherwise shares four of its five subunits with the Golgi-associated retrograde protein (GARP) complex. The EARP complex is localised to recycling to endosomes where it acts as a tethering complex for recycling of plasma membrane receptors [[cite:PUB00077150]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00077150":{"PMID":25799061,"ISBN":null,"volume":"17","issue":"5","year":2015,"title":"EARP is a multisubunit tethering complex involved in endocytic recycling.","URL":null,"raw_pages":"639-50","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Schindler C","Chen Y","Pu J","Guo X","Bonifacino JS."],"DOI_URL":"http://dx.doi.org/10.1038/ncb3129"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":43,"interactions":0,"matches":3139,"pathways":0,"proteins":3084,"proteomes":1737,"sets":1,"structural_models":{"alphafold":2621},"structures":0,"taxa":5463},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":37,"alignment:full":2385},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}