{"metadata":{"accession":"PF10444","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018851","hierarchy":null,"name":{"name":"Nbl1 / Borealin N terminal","short":"Nbl1_Borealin_N"},"description":[{"text":"<p>Nbl1 is a subunit of the conserved CPC, the chromosomal passenger complex, which regulates mitotic chromosome segregation.  In Fungi and Animalia, this complex consists of the kinase Aurora B/AIR-2/Ipl1p, INCENP/ICP-1/Sli15p, and Survivin/BIR-1/Bir1p.  In Animalia, a fourth subunit (Borealin/Dasra/CSC-1) is required for targeting CPC to centromeres and central spindles.  Nbl1 has been shown in budding yeast to be essential for viability, and for CPC localisation, stability, integrity, and function [[cite:PUB00053916]].  The N terminus of Borealin is homologous to Nbl1 [[cite:PUB00053916]].  This family contains both Nbl1, and the N terminal region of Borealin.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00053916":{"PMID":19158380,"ISBN":null,"volume":"20","issue":"6","year":2009,"title":"Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae.","URL":null,"raw_pages":"1772-84","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Nakajima Y","Tyers RG","Wong CC","Yates JR 3rd","Drubin DG","Barnes G."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E08-10-1011"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":20,"interactions":0,"matches":2591,"pathways":0,"proteins":2589,"proteomes":2074,"sets":0,"structural_models":{"alphafold":2226},"structures":13,"taxa":5378},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":60,"alignment:full":2051},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2qfa","name":"Crystal structure of a Survivin-Borealin-INCENP core complex"}}}