{"metadata":{"accession":"PF10344","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR045167","hierarchy":null,"name":{"name":"Hobbit/FMP27/BTLP2 family","short":"Hobbit"},"description":[{"text":"<p>This entry represents the Hobbit protein from Drosophila melanogaster and its homologues such as the mitochondrial FMP27 protein from yeast (also known as Hob1) and BLTP2 (also known as KIAA0100) from human. These proteins are localized to endoplasmic reticulum-plasma membrane (ER-PM) contact sites described as conserved lipid-binding proteins. They are tube-forming transport proteins which bind to phosphatidylinositols and affect phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) distribution [[cite:PUB00101862],[cite:PUB00101860],[cite:PUB00101861]]. They belong to the repeating beta-groove (RBG) superfamily together with VPS13, ATG2, SHIP164, Csf1/BLTP1 proteins, which are all conserved lipid transfer proteins containing long hydrophobic grooves [[cite:PUB00101860],[cite:PUB00101861]]. They all share the same structure consisting of multiple repeating modules comprising five beta-sheets followed by a loop.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101861":{"PMID":35491307,"ISBN":null,"volume":"32","issue":"11","year":2022,"title":"A novel superfamily of bridge-like lipid transfer proteins.","URL":null,"raw_pages":"962-974","medline_journal":"Trends Cell Biol","ISO_journal":"Trends Cell Biol","authors":["Neuman SD","Levine TP","Bashirullah A."],"DOI_URL":null},"PUB00044267":{"PMID":15314641,"ISBN":null,"volume":"36","issue":"9","year":2004,"title":"Gene loops juxtapose promoters and terminators in yeast.","URL":null,"raw_pages":"1014-8","medline_journal":"Nat Genet","ISO_journal":"Nat. Genet.","authors":["O'Sullivan JM","Tan-Wong SM","Morillon A","Lee B","Coles J","Mellor J","Proudfoot NJ."],"DOI_URL":"http://dx.doi.org/10.1038/ng1411"},"PUB00101862":{"PMID":35015055,"ISBN":null,"volume":"221","issue":"3","year":2022,"title":"Vps13-like proteins provide phosphatidylethanolamine for GPI anchor synthesis in the ER.","URL":null,"raw_pages":"e202111095","medline_journal":"J Cell Biol","ISO_journal":"J Cell Biol","authors":["Toulmay A","Whittle FB","Yang J","Bai X","Diarra J","Banerjee S","Levine TP","Golden A","Prinz WA."],"DOI_URL":null},"PUB00101860":{"PMID":34415038,"ISBN":null,"volume":"135","issue":"5","year":2022,"title":"The Hob proteins are novel and conserved lipid-binding proteins at ER-PM contact sites.","URL":null,"raw_pages":"jcs259086","medline_journal":"J Cell Sci","ISO_journal":"J Cell Sci","authors":["Neuman SD","Jorgensen JR","Cavanagh AT","Smyth JT","Selegue JE","Emr SD","Bashirullah A."],"DOI_URL":null}},"set_info":{"accession":"CL0760","name":"RBG"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":118,"interactions":0,"matches":6616,"pathways":0,"proteins":4971,"proteomes":2947,"sets":1,"structural_models":{"alphafold":835},"structures":0,"taxa":7811},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":9,"alignment:full":5067},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}