{"metadata":{"accession":"PF10310","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018814","hierarchy":null,"name":{"name":"Domain of unknown function (DUF5427)","short":"DUF5427"},"description":[{"text":"<p>This is a domain of unknown function. Family members found in Saccharomyces cerevisiae, are synthetic lethal with genes involved in maintenance of telomere capping [[cite:PUB00035474],[cite:PUB00059200]]. However, experimental evidence is yet to verify the exact function of family members and the domain.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00035474":{"PMID":16702403,"ISBN":null,"volume":"20","issue":"10","year":2006,"title":"Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes.","URL":null,"raw_pages":"1294-307","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Fleischer TC","Weaver CM","McAfee KJ","Jennings JL","Link AJ."],"DOI_URL":"http://dx.doi.org/10.1101/gad.1422006"},"PUB00059200":{"PMID":18845848,"ISBN":null,"volume":"180","issue":"4","year":2008,"title":"A genomewide suppressor and enhancer analysis of cdc13-1 reveals varied cellular processes influencing telomere capping in Saccharomyces cerevisiae.","URL":null,"raw_pages":"2251-66","medline_journal":"Genetics","ISO_journal":"Genetics","authors":["Addinall SG","Downey M","Yu M","Zubko MK","Dewar J","Leake A","Hallinan J","Shaw O","James K","Wilkinson DJ","Wipat A","Durocher D","Lydall D."],"DOI_URL":"http://dx.doi.org/10.1534/genetics.108.092577"}},"set_info":{"accession":"CL0342","name":"TolB_N"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":10,"interactions":0,"matches":1472,"pathways":0,"proteins":1436,"proteomes":1389,"sets":1,"structural_models":{"alphafold":1205},"structures":0,"taxa":2883},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":70,"alignment:full":1186},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}