{"metadata":{"accession":"PF10307","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018812","hierarchy":null,"name":{"name":"HAD domain family 1 in Swiss Army Knife RNA repair proteins","short":"HAD_SAK_1"},"description":[{"text":"<p>Family of HAD domain phophoesterases observed in large eukaryotic proteins with predicted role in RNA repair, the so-called 'Swiss Army Knife' repair proteins. May be involved in phosphate group removal during RNA re-ligation [[cite:PUB00091037]].There are two characteristic sequence motifs, GGWW and TGR.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00091037":{"PMID":27536007,"ISBN":null,"volume":"44","issue":"18","year":2016,"title":"RNA damage in biological conflicts and the diversity of responding RNA repair systems.","URL":null,"raw_pages":"8525-8555","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Burroughs AM","Aravind L."],"DOI_URL":"https://doi.org/10.1093/nar/gkw722"}},"set_info":{"accession":"CL0137","name":"HAD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":24,"interactions":0,"matches":1192,"pathways":0,"proteins":1186,"proteomes":1103,"sets":1,"structural_models":{"alphafold":991},"structures":0,"taxa":2287},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":69,"alignment:full":945},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}