{"metadata":{"accession":"PF10300","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019412","hierarchy":null,"name":{"name":"Iml2/Tetratricopeptide repeat protein 39","short":"Iml2-TPR_39"},"description":[{"text":"<p>This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterised proteins.  Members of this family carry a tetratricopeptide repeat [pfam:PF07719] at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localises to the cytoplasm and nucleus [[cite:PUB00016470]], and its expression is increased in response to DNA replication stress [[cite:PUB00066967]]. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress [[cite:PUB00088292]]. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive [[cite:PUB00044224]]. TTC39B has been linked to lipid metabolism [[cite:PUB00072592]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00088292":{"PMID":26004510,"ISBN":null,"volume":"33","issue":"5","year":2015,"title":"Lipid Droplets Are Essential for Efficient Clearance of Cytosolic Inclusion Bodies.","URL":null,"raw_pages":"603-10","medline_journal":"Dev Cell","ISO_journal":"Dev. Cell","authors":["Moldavski O","Amen T","Levin-Zaidman S","Eisenstein M","Rogachev I","Brandis A","Kaganovich D","Schuldiner M."],"DOI_URL":"https://doi.org/10.1016/j.devcel.2015.04.015"},"PUB00066967":{"PMID":22842922,"ISBN":null,"volume":"14","issue":"9","year":2012,"title":"Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress.","URL":null,"raw_pages":"966-76","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Tkach JM","Yimit A","Lee AY","Riffle M","Costanzo M","Jaschob D","Hendry JA","Ou J","Moffat J","Boone C","Davis TN","Nislow C","Brown GW."],"DOI_URL":"http://dx.doi.org/10.1038/ncb2549"},"PUB00016470":{"PMID":14562095,"ISBN":null,"volume":"425","issue":"6959","year":2003,"title":"Global analysis of protein localization in budding yeast.","URL":null,"raw_pages":"686-91","medline_journal":"Nature","ISO_journal":"Nature","authors":["Huh WK","Falvo JV","Gerke LC","Carroll AS","Howson RW","Weissman JS","O'Shea EK."],"DOI_URL":"http://dx.doi.org/10.1038/nature02026"},"PUB00044224":{"PMID":9461476,"ISBN":null,"volume":"26","issue":"4","year":1998,"title":"Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line.","URL":null,"raw_pages":"1116-23","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Kuang WW","Thompson DA","Hoch RV","Weigel RJ."],"DOI_URL":"http://dx.doi.org/10.1093/nar/26.4.1116"},"PUB00072592":{"PMID":21738485,"ISBN":null,"volume":"7","issue":"6","year":2011,"title":"Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.","URL":null,"raw_pages":"e1002138","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet.","authors":["Dumitrescu L","Carty CL","Taylor K","Schumacher FR","Hindorff LA","Ambite JL","Anderson G","Best LG","Brown-Gentry K","Buzkova P","Carlson CS","Cochran B","Cole SA","Devereux RB","Duggan D","Eaton CB","Fornage M","Franceschini N","Haessler J","Howard BV","Johnson KC","Laston S","Kolonel LN","Lee ET","MacCluer JW","Manolio TA","Pendergrass SA","Quibrera M","Shohet RV","Wilkens LR","Haiman CA","Le Marchand L","Buyske S","Kooperberg C","North KE","Crawford DC."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pgen.1002138"}},"set_info":{"accession":"CL0020","name":"TPR"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":143,"interactions":0,"matches":9867,"pathways":0,"proteins":9006,"proteomes":2835,"sets":1,"structural_models":{"alphafold":7859},"structures":0,"taxa":7559},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":17,"alignment:full":8090},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}