{"metadata":{"accession":"PF10282","entry_id":null,"type":"repeat","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019405","hierarchy":null,"name":{"name":"Lactonase, 7-bladed beta-propeller","short":"Lactonase"},"description":[{"text":"<p>This entry contains bacterial 6-phosphogluconolactonases (6PGL)YbhE-type ([ec:3.1.1.31]) which hydrolyse 6-phosphogluconolactone to 6-phosphogluconate. The entry also contains the fungal muconate lactonising enzyme carboxy-cis,cis-muconate cyclase ([ec:5.5.1.5]) and muconate cycloisomerase ([ec:5.5.1.1]), which convert cis,cis-muconates to muconolactones and vice versa as part of the microbial beta-ketoadipate pathway.                          Structures of proteins in this family have revealed a 7-bladed beta-propeller fold [[cite:PUB00037024]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Lactonase","extract":"<p><b>Lactonase</b> (EC 3.1.1.81, <b>acyl-homoserine lactonase</b>; systematic name <b><i>N</i>-acyl-<small>L</small>-homoserine-lactone lactonohydrolase</b>) is a metalloenzyme, produced by certain species of bacteria, which targets and inactivates acylated homoserine lactones (AHLs). It catalyzes the reaction</p><dl><dd>an <i>N</i>-acyl-<small>L</small>-homoserine lactone + H<sub>2</sub>O <span class=\"mwe-math-element mwe-math-element-inline\"><img src=\"https://wikimedia.org/api/rest_v1/media/math/render/svg/1c37b981df851b9e54e489e017b1481e37d418f3\" class=\"mwe-math-fallback-image-inline mw-invert skin-invert\" aria-hidden=\"true\" style=\"vertical-align:-0.338ex;width:2.324ex;height:1.843ex\" /></span> an <i>N</i>-acyl-<small>L</small>-homoserine</dd></dl>","thumbnail":null}],"literature":{"PUB00037024":{"PMID":11937053,"ISBN":null,"volume":"10","issue":"4","year":2002,"title":"The structure of Neurospora crassa 3-carboxy-cis,cis-muconate lactonizing enzyme, a beta propeller cycloisomerase.","URL":null,"raw_pages":"483-92","medline_journal":"Structure","ISO_journal":"Structure","authors":["Kajander T","Merckel MC","Thompson A","Deacon AM","Mazur P","Kozarich JW","Goldman A."],"DOI_URL":"http://dx.doi.org/10.1016/S0969-2126(02)00744-X"}},"set_info":{"accession":"CL0186","name":"Beta_propeller"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":523,"interactions":0,"matches":22059,"pathways":0,"proteins":20552,"proteomes":10997,"sets":1,"structural_models":{"alphafold":13530},"structures":10,"taxa":16490},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":50,"alignment:full":12688},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6igb","name":"the structure of Pseudomonas aeruginosa Periplasmic gluconolactonase, PpgL"}}}