{"metadata":{"accession":"PF10265","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019392","hierarchy":null,"name":{"name":"Mitoguardin","short":"Miga"},"description":[{"text":"<p>Mitoguardin (Miga) was first identified in flies as a mitochondrial outer-membrane protein that promotes mitochondrial fusion. Later, the mammalian Miga homologues, Miga1 and Miga2, were identified. They are found to promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD [[cite:PUB00077967],[cite:PUB00077968]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00077967":{"PMID":26711011,"ISBN":null,"volume":"61","issue":"1","year":2016,"title":"Mitoguardin Regulates Mitochondrial Fusion through MitoPLD and Is Required for Neuronal Homeostasis.","URL":null,"raw_pages":"111-24","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Zhang Y","Liu X","Bai J","Tian X","Zhao X","Liu W","Duan X","Shang W","Fan HY","Tong C."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2015.11.017"},"PUB00077968":{"PMID":26716412,"ISBN":null,"volume":null,"issue":null,"year":2015,"title":"Mitoguardin-1 and -2 promote maturation and the developmental potential of mouse oocytes by maintaining mitochondrial dynamics and functions.","URL":null,"raw_pages":null,"medline_journal":"Oncotarget","ISO_journal":"Oncotarget","authors":["Liu XM","Zhang YP","Ji SY","Li BT","Tian X","Li D","Tong C","Fan HY."],"DOI_URL":"http://dx.doi.org/10.18632/oncotarget.6713"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":36,"interactions":0,"matches":3183,"pathways":0,"proteins":2970,"proteomes":1243,"sets":0,"structural_models":{"alphafold":2653},"structures":3,"taxa":4033},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":21,"alignment:full":2637},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}