{"metadata":{"accession":"PF10231","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018796","hierarchy":null,"name":{"name":"Cytochrome c oxidase assembly factor 8","short":"COA8"},"description":[{"text":"<p>Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway [[cite:PUB00086677]], is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS) [[cite:PUB00093669]]. In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions [[cite:PUB00093671]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093671":{"PMID":31555154,"ISBN":null,"volume":"10","issue":null,"year":2019,"title":"Knockdown of APOPT1/COA8 Causes Cytochrome c Oxidase Deficiency, Neuromuscular Impairment, and Reduced Resistance to Oxidative Stress in Drosophila melanogaster.","URL":null,"raw_pages":"1143","medline_journal":"Front Physiol","ISO_journal":"Front Physiol","authors":["Brischigliaro M","Corra S","Tregnago C","Fernandez-Vizarra E","Zeviani M","Costa R","De Pitta C."],"DOI_URL":null},"PUB00093669":{"PMID":30552096,"ISBN":null,"volume":"11","issue":"1","year":2019,"title":"APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.","URL":null,"raw_pages":null,"medline_journal":"EMBO Mol Med","ISO_journal":"EMBO Mol Med","authors":["Signes A","Cerutti R","Dickson AS","Beninca C","Hinchy EC","Ghezzi D","Carrozzo R","Bertini E","Murphy MP","Nathan JA","Viscomi C","Fernandez-Vizarra E","Zeviani M."],"DOI_URL":null},"PUB00086677":{"PMID":16782708,"ISBN":null,"volume":"281","issue":"33","year":2006,"title":"Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis.","URL":null,"raw_pages":"23899-907","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Yasuda O","Fukuo K","Sun X","Nishitani M","Yotsui T","Higuchi M","Suzuki T","Rakugi H","Smithies O","Maeda N","Ogihara T."],"DOI_URL":"https://doi.org/10.1074/jbc.M512610200"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":41,"interactions":0,"matches":1842,"pathways":0,"proteins":1836,"proteomes":1499,"sets":0,"structural_models":{"alphafold":1633},"structures":0,"taxa":4636},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":30,"alignment:full":1480},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}