{"metadata":{"accession":"PF10226","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019359","hierarchy":null,"name":{"name":"CCDC85 family","short":"CCDC85"},"description":[{"text":"<p>This entry includes human CCDC85A/B/C and C. elegans  Picc-1 protein. Picc-1 serves as  a linker protein which helps  to recruit the Rho GTPase-activating protein, pac-1, to  adherens junctions [[cite:PUB00078905]]. Human CCDC85B suppresses the  beta-catenin activity in a p53-dependent manner [[cite:PUB00078906]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00078905":{"PMID":25938815,"ISBN":null,"volume":"17","issue":"6","year":2015,"title":"An instructive role for C. elegans E-cadherin in translating cell contact cues into cortical polarity.","URL":null,"raw_pages":"726-35","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Klompstra D","Anderson DC","Yeh JY","Zilberman Y","Nance J."],"DOI_URL":"http://dx.doi.org/10.1038/ncb3168"},"PUB00078906":{"PMID":17873903,"ISBN":null,"volume":"27","issue":"11","year":2008,"title":"Coiled-coil domain containing 85B suppresses the beta-catenin activity in a p53-dependent manner.","URL":null,"raw_pages":"1520-6","medline_journal":"Oncogene","ISO_journal":"Oncogene","authors":["Iwai A","Hijikata M","Hishiki T","Isono O","Chiba T","Shimotohno K."],"DOI_URL":"http://dx.doi.org/10.1038/sj.onc.1210801"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":28,"interactions":0,"matches":3556,"pathways":0,"proteins":3544,"proteomes":1178,"sets":0,"structural_models":{"alphafold":3112},"structures":0,"taxa":3878},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":12,"alignment:full":2718},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}