{"metadata":{"accession":"PF10223","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019356","hierarchy":null,"name":{"name":"Menorin N-terminal domain","short":"Menorin_N"},"description":[{"text":"<p>This entyr includes proteins FAM151A and FAM151B, the mammalian homologues of C. elegans menorin which is involved in generation of neurons and regulation of dendrite extension [[cite:PUB00100987],[cite:PUB00100988]]. FAM151B has been shown to be essential for retinal function [[cite:PUB00100987]]. Sequence analysis and the fact that these proteins have a TIM-barrel fold similar to that in phospholipase D and glycerophosphodiester phosphodiesterase (GDPD) families, indicate that they belong to PLC-like phosphodiesterase superfamily, although their substrates and function remain unknown. According to structure predictions, this domain is found at the N-terminal of menorin while in FAM151A is found twice and in FAM151B which is much shorter, it is the only domain present.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00100987":{"PMID":31949211,"ISBN":null,"volume":"10","issue":"1","year":2020,"title":"Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.","URL":null,"raw_pages":"437","medline_journal":"Sci Rep","ISO_journal":"Sci Rep","authors":["Findlay AS","McKie L","Keighren M","Clementson-Mobbs S","Sanchez-Pulido L","Wells S","Cross SH","Jackson IJ."],"DOI_URL":null},"PUB00100988":{"PMID":34197450,"ISBN":null,"volume":"17","issue":"7","year":2021,"title":"The CATP-8/P5A-type ATPase functions in multiple pathways during neuronal patterning.","URL":null,"raw_pages":"e1009475","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet","authors":["Tang LTH","Trivedi M","Freund J","Salazar CJ","Rahman M","Ramirez-Suarez NJ","Lee G","Wang Y","Grant BD","Bulow HE."],"DOI_URL":null}},"set_info":{"accession":"CL0036","name":"TIM_barrel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":42,"interactions":0,"matches":2741,"pathways":0,"proteins":2267,"proteomes":1273,"sets":1,"structural_models":{"alphafold":1940},"structures":0,"taxa":4141},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":53,"alignment:full":2099},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}