{"metadata":{"accession":"PF10220","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019354","hierarchy":null,"name":{"name":"Smg8_Smg9","short":"Smg8_Smg9"},"description":[{"text":"<p>Smg8 and Smg9 are two subunits of the Smg-1 complex. They suppress Smg-1 kinase activity in the isolated Smg-1  complex, and are involved in nonsense-mediated mRNA  decay (NMD) in both mammals and nematodes [[cite:PUB00054170]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00054170":{"PMID":19417104,"ISBN":null,"volume":"23","issue":"9","year":2009,"title":"SMG-8 and SMG-9, two novel subunits of the SMG-1 complex, regulate remodeling of the mRNA surveillance complex during nonsense-mediated mRNA decay.","URL":null,"raw_pages":"1091-105","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Yamashita A","Izumi N","Kashima I","Ohnishi T","Saari B","Katsuhata Y","Muramatsu R","Morita T","Iwamatsu A","Hachiya T","Kurata R","Hirano H","Anderson P","Ohno S."],"DOI_URL":"http://dx.doi.org/10.1101/gad.1767209"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":58,"interactions":0,"matches":3813,"pathways":0,"proteins":2394,"proteomes":1604,"sets":0,"structural_models":{"alphafold":1986},"structures":8,"taxa":5105},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":21,"alignment:full":2679},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}