{"metadata":{"accession":"PF10218","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019352","hierarchy":null,"name":{"name":"SREBP regulating gene protein","short":"SPRING1"},"description":[{"text":"<p>SPRING1 is a glycosylated Golgi-resident membrane protein involved in SREBP signaling and cholesterol metabolism. It modulates the proper localisation of SCAP (SREBP cleavage-activating protein) to the endoplasmic reticulum, thereby controlling the level of functional SCAP [[cite:PUB00094523]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094523":{"PMID":32111832,"ISBN":null,"volume":"11","issue":"1","year":2020,"title":"Haploid genetic screens identify SPRING/C12ORF49 as a determinant of SREBP signaling and cholesterol metabolism.","URL":null,"raw_pages":"1128","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Loregger A","Raaben M","Nieuwenhuis J","Tan JME","Jae LT","van den Hengel LG","Hendrix S","van den Berg M","Scheij S","Song JY","Huijbers IJ","Kroese LJ","Ottenhoff R","van Weeghel M","van de Sluis B","Brummelkamp T","Zelcer N."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":22,"interactions":0,"matches":2190,"pathways":0,"proteins":2163,"proteomes":1532,"sets":0,"structural_models":{"alphafold":1856},"structures":2,"taxa":4943},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":38,"alignment:full":1581},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}