{"metadata":{"accession":"PF10178","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018788","hierarchy":null,"name":{"name":"Proteasome assembly chaperone 3","short":"PAC3"},"description":[{"text":"<p>PAC3 is a family of eukaryotic proteasome assembly chaperone 3 proteins conserved from fungi to plants to humans. PAC3 plays a crucial part in the assembly of the 20S core proteasome unit, in conjunction with PAC4.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044884":{"PMID":17189198,"ISBN":null,"volume":"24","issue":"6","year":2006,"title":"Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes.","URL":null,"raw_pages":"977-84","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Hirano Y","Hayashi H","Iemura S","Hendil KB","Niwa S","Kishimoto T","Kasahara M","Natsume T","Tanaka K","Murata S."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2006.11.015"},"PUB00044197":{"PMID":18278057,"ISBN":null,"volume":"15","issue":"3","year":2008,"title":"Crystal structure of a chaperone complex that contributes to the assembly of yeast 20S proteasomes.","URL":null,"raw_pages":"228-36","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Yashiroda H","Mizushima T","Okamoto K","Kameyama T","Hayashi H","Kishimoto T","Niwa S","Kasahara M","Kurimoto E","Sakata E","Takagi K","Suzuki A","Hirano Y","Murata S","Kato K","Yamane T","Tanaka K."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb.1386"},"PUB00044890":{"PMID":17707236,"ISBN":null,"volume":"27","issue":"4","year":2007,"title":"20S proteasome assembly is orchestrated by two distinct pairs of chaperones in yeast and in mammals.","URL":null,"raw_pages":"660-74","medline_journal":"Mol Cell","ISO_journal":"Mol. Cell","authors":["Le Tallec B","Barrault MB","Courbeyrette R","Guerois R","Marsolier-Kergoat MC","Peyroche A."],"DOI_URL":"http://dx.doi.org/10.1016/j.molcel.2007.06.025"}},"set_info":{"accession":"CL0765","name":"PAC"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":32,"interactions":0,"matches":2250,"pathways":0,"proteins":2245,"proteomes":1893,"sets":1,"structural_models":{"alphafold":1936},"structures":4,"taxa":5707},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":33,"alignment:full":1686},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"6jpt","name":"Crystal structure of human PAC3 homodimer (trigonal form)"}}}