{"metadata":{"accession":"PF10176","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019325","hierarchy":null,"name":{"name":"NEDD4/Bsd2","short":"NEDD4_Bsd2"},"description":[{"text":"<p>Proteins in this entry includes NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostasis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases [[cite:PUB00075325],[cite:PUB00075323]]. Ndfip1 plays a role in regulating metal transport in human neurons [[cite:PUB00075324]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00075325":{"PMID":19343052,"ISBN":null,"volume":"10","issue":"5","year":2009,"title":"Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins.","URL":null,"raw_pages":"501-7","medline_journal":"EMBO Rep","ISO_journal":"EMBO Rep.","authors":["Mund T","Pelham HR."],"DOI_URL":"http://dx.doi.org/10.1038/embor.2009.30"},"PUB00075324":{"PMID":19706893,"ISBN":null,"volume":"106","issue":"36","year":2009,"title":"Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons.","URL":null,"raw_pages":"15489-94","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Howitt J","Putz U","Lackovic J","Doan A","Dorstyn L","Cheng H","Yang B","Chan-Ling T","Silke J","Kumar S","Tan SS."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0904880106"},"PUB00075323":{"PMID":20534535,"ISBN":null,"volume":"107","issue":"25","year":2010,"title":"Regulation of PTEN/Akt and MAP kinase signaling pathways by the ubiquitin ligase activators Ndfip1 and Ndfip2.","URL":null,"raw_pages":"11429-34","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Mund T","Pelham HR."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.0911714107"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":51,"interactions":0,"matches":6814,"pathways":0,"proteins":4457,"proteomes":2520,"sets":0,"structural_models":{"alphafold":3903},"structures":0,"taxa":6609},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":65,"alignment:full":5447},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}