{"metadata":{"accession":"PF10164","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019317","hierarchy":null,"name":{"name":"Brain protein I3","short":"BRI3"},"description":[{"text":"<p>This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3) [[cite:PUB00083183]]. Their function is unknown but they appear to play a role in TNF-induced cell death [[cite:PUB00095376]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00083183":{"PMID":11290423,"ISBN":null,"volume":"266","issue":"1-2","year":2001,"title":"Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family.","URL":null,"raw_pages":"95-102","medline_journal":"Gene","ISO_journal":"Gene","authors":["Vidal R","Calero M","Revesz T","Plant G","Ghiso J","Frangione B."],"DOI_URL":"http://dx.doi.org/10.1016/S0378-1119(01)00374-2"},"PUB00095376":{"PMID":14592447,"ISBN":null,"volume":"311","issue":"2","year":2003,"title":"bri3, a novel gene, participates in tumor necrosis factor-alpha-induced cell death.","URL":null,"raw_pages":"518-24","medline_journal":"Biochem Biophys Res Commun","ISO_journal":"Biochem. Biophys. Res. Commun.","authors":["Wu H","Liu G","Li C","Zhao S."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":1731,"pathways":0,"proteins":1725,"proteomes":1240,"sets":0,"structural_models":{"alphafold":1526},"structures":0,"taxa":4040},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":1375},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}