{"metadata":{"accession":"PF10154","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019311","hierarchy":null,"name":{"name":"Ferry endosomal RAB5 effector complex subunit 3","short":"Fy-3"},"description":[{"text":"<p>This entry represents a human Ferry endosomal RAB5 effector complex subunit 3 (Fy-3) and similar sequences from animals and some fungal species. Fy-3 is a component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary), which is involved in the localisation and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction [[cite:PUB00152264]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00153730":{"PMID":37267905,"ISBN":null,"volume":"83","issue":"11","year":2023,"title":"The Rab5 effector FERRY links early endosomes with mRNA localization.","URL":null,"raw_pages":"1839-1855.e13","medline_journal":"Mol Cell","ISO_journal":"Mol Cell","authors":["Schuhmacher JS","Tom Dieck S","Christoforidis S","Landerer C","Davila Gallesio J","Hersemann L","Seifert S","Schafer R","Giner A","Toth-Petroczy A","Kalaidzidis Y","Bohnsack KE","Bohnsack MT","Schuman EM","Zerial M."],"DOI_URL":"https://doi.org/10.1016/j.molcel.2023.05.012"},"PUB00152264":{"PMID":31106069,"ISBN":null,"volume":"7","issue":null,"year":2019,"title":"A novel conserved family of Macro-like domains-putative new players in ADP-ribosylation signaling.","URL":null,"raw_pages":"e6863","medline_journal":"PeerJ","ISO_journal":"PeerJ","authors":["Dudkiewicz M","Pawlowski K."],"DOI_URL":"https://doi.org/10.7717/peerj.6863"}},"set_info":{"accession":"CL0223","name":"MACRO"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":44,"interactions":0,"matches":2297,"pathways":0,"proteins":1971,"proteomes":1364,"sets":1,"structural_models":{"alphafold":1732},"structures":0,"taxa":4364},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":11,"alignment:full":1861},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}