{"metadata":{"accession":"PF10104","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018767","hierarchy":null,"name":{"name":"Di-sulfide bridge nucleocytoplasmic transport domain","short":"Brr6_like_C_C"},"description":[{"text":"<p>Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi. It carries four highly conserved cysteine residues. It is suggested that members of the family interact with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport [[cite:PUB00044174]]. Brr6 in yeast is an essential integral membrane protein of the NE-ER, wit two predicted transmembrane domains, and is a dosage suppressor of Apq12, [pfam:PF12716] [[cite:PUB00055994]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044174":{"PMID":15882446,"ISBN":null,"volume":"6","issue":"6","year":2005,"title":"Brl1p -- a novel nuclear envelope protein required for nuclear transport.","URL":null,"raw_pages":"502-17","medline_journal":"Traffic","ISO_journal":"Traffic","authors":["Saitoh YH","Ogawa K","Nishimoto T."],"DOI_URL":"http://dx.doi.org/10.1111/j.1600-0854.2005.00295.x"},"PUB00055994":{"PMID":20016074,"ISBN":null,"volume":"123","issue":"Pt 1","year":2010,"title":"Integral membrane proteins Brr6 and Apq12 link assembly of the nuclear pore complex to lipid homeostasis in the endoplasmic reticulum.","URL":null,"raw_pages":"141-51","medline_journal":"J Cell Sci","ISO_journal":"J. Cell. Sci.","authors":["Hodge CA","Choudhary V","Wolyniak MJ","Scarcelli JJ","Schneiter R","Cole CN."],"DOI_URL":"http://dx.doi.org/10.1242/jcs.055046"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":33,"interactions":0,"matches":1891,"pathways":0,"proteins":1884,"proteomes":1570,"sets":0,"structural_models":{"alphafold":1583},"structures":0,"taxa":3350},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":125,"alignment:full":1508},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}