{"metadata":{"accession":"PF10074","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018754","hierarchy":null,"name":{"name":"T6SS, Transcription factor, DNA binding domain","short":"RovC_DNA-bd"},"description":[{"text":"<p>This domain is found in a group of proteins from proteobacteria, including the hexameric transcription factor from Yersinia pseudotuberculosis RovC, which is essential for the activation of one of the Type VI secretion systems of this organism (T6SS4). This domain folds into a distinct variant of the helix-turn-helix domain that shows an 'extended-turn' motif. It is responsible for DNA binding, participating in transcriptional activation and antiactivation to initiate or inhibit horizontal gene transfer [[cite:PUB00152791],[cite:PUB00152792]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00152792":{"PMID":37246713,"ISBN":null,"volume":"51","issue":"13","year":2023,"title":"DUF2285 is a novel helix-turn-helix domain variant that orchestrates both activation and antiactivation of conjugative element transfer in proteobacteria.","URL":null,"raw_pages":"6841-6856","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res","authors":["Jowsey WJ","Morris CRP","Hall DA","Sullivan JT","Fagerlund RD","Eto KY","Solomon PD","Mackay JP","Bond CS","Ramsay JP","Ronson CW."],"DOI_URL":"https://doi.org/10.1093/nar/gkad457"},"PUB00152791":{"PMID":32966346,"ISBN":null,"volume":"16","issue":"9","year":2020,"title":"RovC - a novel type of hexameric transcriptional activator promoting type VI secretion gene expression.","URL":null,"raw_pages":"e1008552","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog","authors":["Knittel V","Sadana P","Seekircher S","Stolle AS","Korner B","Volk M","Jeffries CM","Svergun DI","Heroven AK","Scrima A","Dersch P."],"DOI_URL":"https://doi.org/10.1371/journal.ppat.1008552"}},"set_info":{"accession":"CL0123","name":"HTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":12,"interactions":0,"matches":2443,"pathways":0,"proteins":2443,"proteomes":1012,"sets":1,"structural_models":{"alphafold":1599},"structures":2,"taxa":1628},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":43,"alignment:full":1242},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}