{"metadata":{"accession":"PF10040","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019267","hierarchy":null,"name":{"name":"CRISPR-associated endoribonuclease Cas6","short":"CRISPR_Cas6"},"description":[{"text":"<p>Cas6 is a member of the RAMP (repeat-associated mysterious protein) superfamily [[cite:PUB00043288]]. It is among the most widely distributed Cas proteins and is found in both bacteria and archaea [[cite:PUB00020781]]. Cas6 functions in the generation of CRISPR-derived guide RNAs for invader defense in prokaryotes [[cite:PUB00054084]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00043288":{"PMID":16545108,"ISBN":null,"volume":"1","issue":null,"year":2006,"title":"A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action.","URL":null,"raw_pages":"7","medline_journal":"Biol Direct","ISO_journal":"Biol. Direct","authors":["Makarova KS","Grishin NV","Shabalina SA","Wolf YI","Koonin EV."],"DOI_URL":"http://dx.doi.org/10.1186/1745-6150-1-7"},"PUB00020781":{"PMID":16292354,"ISBN":null,"volume":"1","issue":"6","year":2005,"title":"A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.","URL":null,"raw_pages":"e60","medline_journal":"PLoS Comput Biol","ISO_journal":"PLoS Comput. Biol.","authors":["Haft DH","Selengut J","Mongodin EF","Nelson KE."],"DOI_URL":"http://dx.doi.org/10.1371/journal.pcbi.0010060"},"PUB00054084":{"PMID":19141480,"ISBN":null,"volume":"22","issue":"24","year":2008,"title":"Cas6 is an endoribonuclease that generates guide RNAs for invader defense in prokaryotes.","URL":null,"raw_pages":"3489-96","medline_journal":"Genes Dev","ISO_journal":"Genes Dev.","authors":["Carte J","Wang R","Li H","Terns RM","Terns MP."],"DOI_URL":"http://dx.doi.org/10.1101/gad.1742908"}},"set_info":{"accession":"CL0362","name":"RAMPS-Cas5-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":1540,"pathways":0,"proteins":1540,"proteomes":1154,"sets":1,"structural_models":{"alphafold":1115},"structures":11,"taxa":2835},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":147,"alignment:full":1021},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}