{"metadata":{"accession":"PF10034","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018732","hierarchy":null,"name":{"name":"Q-cell neuroblast polarisation","short":"Dpy19"},"description":[{"text":"<p>Dyp-19, formerly known as DUF2211, is a transmembrane domain family that is required to orient the neuroblast cells, QR and QL accurately on the anterior-posterior axis: QL and QR are born in the same anterior-posterior position, but polarise and migrate left-right asymmetrically, QL migrating towards the posterior and QR migrating towards the anterior. It is also required, with unc-40, to express mab-5 correctly in the Q cell descendants [[cite:PUB00044879]]. The Dpy-19 protein derives from the C. elegans DUMPY mutant, [swissprot:P34413].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00044879":{"PMID":11023868,"ISBN":null,"volume":"127","issue":"21","year":2000,"title":"Establishment of left/right asymmetry in neuroblast migration by UNC-40/DCC, UNC-73/Trio and DPY-19 proteins in C. elegans.","URL":null,"raw_pages":"4655-68","medline_journal":"Development","ISO_journal":"Development","authors":["Honigberg L","Kenyon C."],"DOI_URL":null}},"set_info":{"accession":"CL0111","name":"GT-C"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":53,"interactions":0,"matches":5527,"pathways":0,"proteins":4728,"proteomes":1248,"sets":1,"structural_models":{"alphafold":4145},"structures":4,"taxa":3917},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":42,"alignment:full":4696},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}