This domain, found in various hypothetical bacterial proteins and misannotated lysozyme proteins, it has no known function. This domain contains a [S/T]GA[S/T] conserved motif and serves as a flavinylation substrate for ApbE, and is likely to be involved in extracytosolic redox activities [[cite:PUB00098250]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00098250":{"PMID":34032212,"ISBN":null,"volume":"10","issue":null,"year":2021,"title":"Post-translational flavinylation is associated with diverse extracytosolic redox functionalities throughout bacterial life.","URL":null,"raw_pages":null,"medline_journal":"Elife","ISO_journal":"Elife","authors":["Meheust R","Huang S","Rivera-Lugo R","Banfield JF","Light SH."],"DOI_URL":null}},"set_info":{"accession":"CL0159","name":"E-set"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":4,"interactions":0,"matches":2764,"pathways":0,"proteins":2764,"proteomes":2590,"sets":1,"structural_models":{"alphafold":1695},"structures":0,"taxa":3726},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":76,"alignment:full":1303},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}