{"metadata":{"accession":"PF10021","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019261","hierarchy":null,"name":{"name":"Microbial-type PARG, catalytic domain","short":"PARG_cat_microb"},"description":[{"text":"<p>Poly(ADP-ribose) glycohydrolase (PARG) hydrolyses the ribose-ribose bonds present in poly(ADP-ribose) (PAR) chains. This entry represents the PARG homologue present in bacteria and fungi. Its structure shows a typical macrodomain folding consisting of a seven-stranded beta-sheet sandwiched between nine alpha-helices [[cite:PUB00065612],[cite:PUB00100174]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00065612":{"PMID":21892188,"ISBN":null,"volume":"477","issue":"7366","year":2011,"title":"The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase.","URL":null,"raw_pages":"616-20","medline_journal":"Nature","ISO_journal":"Nature","authors":["Slade D","Dunstan MS","Barkauskaite E","Weston R","Lafite P","Dixon N","Ahel M","Leys D","Ahel I."],"DOI_URL":"http://dx.doi.org/10.1038/nature10404"},"PUB00100174":{"PMID":30940816,"ISBN":null,"volume":"10","issue":"1","year":2019,"title":"Structural and biochemical evidence supporting poly ADP-ribosylation in the bacterium Deinococcus radiodurans.","URL":null,"raw_pages":"1491","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Cho CC","Chien CY","Chiu YC","Lin MH","Hsu CH."],"DOI_URL":null}},"set_info":{"accession":"CL0223","name":"MACRO"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":107,"interactions":0,"matches":4787,"pathways":0,"proteins":4774,"proteomes":2775,"sets":1,"structural_models":{"alphafold":3399},"structures":11,"taxa":4944},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":52,"alignment:full":3415},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3sig","name":"The X-ray crystal structure of poly(ADP-ribose) glycohydrolase (PARG) bound to ADP-ribose from Thermomonospora curvata"}}}