{"metadata":{"accession":"PF10017","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019257","hierarchy":null,"name":{"name":"Histidine-specific methyltransferase, SAM-dependent","short":"Methyltransf_33"},"description":[{"text":"<p>The mycobacterial members of this family are expressed from part of the ergothioneine biosynthetic gene cluster. EGTD is the histidine methyltransferase that transfers three methyl groups to the alpha-amino moiety of histidine, in the first stage of the production of this histidine betaine derivative that carries a thiol group attached to the C2 atom of an imidazole ring [[cite:PUB00060032]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00060032":{"PMID":20420449,"ISBN":null,"volume":"132","issue":"19","year":2010,"title":"In vitro reconstitution of Mycobacterial ergothioneine biosynthesis.","URL":null,"raw_pages":"6632-3","medline_journal":"J Am Chem Soc","ISO_journal":"J. Am. Chem. Soc.","authors":["Seebeck FP."],"DOI_URL":"http://dx.doi.org/10.1021/ja101721e"}},"set_info":{"accession":"CL0063","name":"NADP_Rossmann"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":79,"interactions":0,"matches":9704,"pathways":0,"proteins":9308,"proteomes":7637,"sets":1,"structural_models":{"alphafold":6174},"structures":17,"taxa":11798},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":215,"alignment:full":5715},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7sew","name":"M. tb EgtD in complex with HD6"}}}