This domain is found in Uncharacterized protein MJ0754 from Methanocaldococcus jannaschii and similar proteins from bacteria and archaea. MJ0754 adopts a dimeric assembly, with each monomer consisting of six alpha-helices [[cite:PUB00100681]]. It is a member of a broad superfamily of ferritin-like diiron-carboxylate proteins whose function is unknown. The conserved residues of a diiron centre are present within the putative active site.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00100681":{"PMID":21604308,"ISBN":null,"volume":"79","issue":"7","year":2011,"title":"Structural insights into the metal binding properties of hypothetical protein MJ0754 from Methanococcus jannaschii.","URL":null,"raw_pages":"2358-63","medline_journal":"Proteins","ISO_journal":"Proteins","authors":["Lee EH","Kim HS","Kim HY","Jeon YH","Hwang KY."],"DOI_URL":null}},"set_info":{"accession":"CL0044","name":"Ferritin"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":9,"interactions":0,"matches":762,"pathways":0,"proteins":758,"proteomes":658,"sets":1,"structural_models":{"alphafold":544},"structures":4,"taxa":1461},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":392},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"3q4o","name":"Crystal Structure of a deletion mutant(11-185) of hypothetical protein MJ0754 determined to 1.34A"}}}