{"metadata":{"accession":"PF09954","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR018691","hierarchy":null,"name":{"name":"Uncharacterized protein conserved in bacteria (DUF2188)","short":"DUF2188"},"description":[{"text":"<p>This domain represents a ribosome-associating protein predicted to mediate translation inhibition alongside repair of DNA damage or restriction in conflict contexts. A subset of this family contains a conserved histidine residue, raising the possibility that it directly acts as a RNase or in RNA end-processing [[cite:PUB00097693]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"<p>A <b>domain of unknown function</b> (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.</p>","thumbnail":null}],"literature":{"PUB00097693":{"PMID":32868406,"ISBN":null,"volume":"202","issue":"24","year":2020,"title":"Identification of Uncharacterized Components of Prokaryotic Immune Systems and Their Diverse Eukaryotic Reformulations.","URL":null,"raw_pages":null,"medline_journal":"J Bacteriol","ISO_journal":"J Bacteriol","authors":["Burroughs AM","Aravind L."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":15,"interactions":0,"matches":3990,"pathways":0,"proteins":3987,"proteomes":3119,"sets":0,"structural_models":{"alphafold":2476},"structures":0,"taxa":5021},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":92,"alignment:full":1817},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}