{"metadata":{"accession":"PF09949","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR019236","hierarchy":null,"name":{"name":"Phosphatidate phosphatase APP1, catalytic domain","short":"APP1_cat"},"description":[{"text":"<p>This entry represents a conserved region found in Phosphatidate phosphatase APP1 from yeast, which contains the catalytic motif DXDX(T/V) [[cite:PUB00071676],[cite:PUB00098278]], present in other Mg+2-dependent phosphatases. This domain has a weak sequence similarity to the haloacid dehalogenase-like domain [[cite:PUB00071676]]. APP1 catalyses the dephosphorylation of phosphatidate to yield diacylglycerol and may play a role in vesicular trafficking through its phosphatidate phosphatase activity at cortical actin patches [[cite:PUB00071676],[cite:PUB00098278]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00071676":{"PMID":23071111,"ISBN":null,"volume":"287","issue":"48","year":2012,"title":"The Saccharomyces cerevisiae actin patch protein App1p is a phosphatidate phosphatase enzyme.","URL":null,"raw_pages":"40186-96","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Chae M","Han GS","Carman GM."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.M112.421776"},"PUB00098278":{"PMID":23335564,"ISBN":null,"volume":"288","issue":"9","year":2013,"title":"Characterization of the yeast actin patch protein App1p phosphatidate phosphatase.","URL":null,"raw_pages":"6427-37","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Chae M","Carman GM."],"DOI_URL":null}},"set_info":{"accession":"CL0137","name":"HAD"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":76,"interactions":0,"matches":7431,"pathways":0,"proteins":7412,"proteomes":4992,"sets":1,"structural_models":{"alphafold":5212},"structures":0,"taxa":7879},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":167,"alignment:full":4782},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}