{"metadata":{"accession":"PF09924","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR024320","hierarchy":null,"name":{"name":"Phosphatidylglycerol lysyltransferase, C-terminal","short":"LPG_synthase_C"},"description":[{"text":"<p>This domain can be found in the C-terminal region of phosphatidylglycerol lysyltransferase mprF, which catalyses the transfer of a lysyl group from L-lysyl-tRNA(Lys) to to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG) [[cite:PUB00056129],[cite:PUB00109263]]. This domain can also be found in lysylphosphatidylglycerol biosynthesis bifunctional protein LysX, which is the two-domain lysyl-transferase (mprF)-lysyl-tRNA synthetase (lysU) protein is responsible for LPG production [[cite:PUB00078731]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00078731":{"PMID":19649276,"ISBN":null,"volume":"5","issue":"7","year":2009,"title":"The two-domain LysX protein of Mycobacterium tuberculosis is required for production of lysinylated phosphatidylglycerol and resistance to cationic antimicrobial peptides.","URL":null,"raw_pages":"e1000534","medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog.","authors":["Maloney E","Stankowska D","Zhang J","Fol M","Cheng QJ","Lun S","Bishai WR","Rajagopalan M","Chatterjee D","Madiraju MV."],"DOI_URL":"http://dx.doi.org/10.1371/journal.ppat.1000534"},"PUB00056129":{"PMID":14769468,"ISBN":null,"volume":"231","issue":"1","year":2004,"title":"MprF-mediated biosynthesis of lysylphosphatidylglycerol, an important determinant in staphylococcal defensin resistance.","URL":null,"raw_pages":"67-71","medline_journal":"FEMS Microbiol Lett","ISO_journal":"FEMS Microbiol. Lett.","authors":["Staubitz P","Neumann H","Schneider T","Wiedemann I","Peschel A."],"DOI_URL":"http://dx.doi.org/10.1016/S0378-1097(03)00921-2"},"PUB00109263":{"PMID":30563904,"ISBN":null,"volume":"9","issue":"6","year":2018,"title":"Gain-of-Function Mutations in the Phospholipid Flippase MprF Confer Specific Daptomycin Resistance. ","URL":null,"raw_pages":"e01659-18","medline_journal":"mBio","ISO_journal":"mBio","authors":["Ernst CM","Slavetinsky CJ","Kuhn S","Hauser JN","Nega M","Mishra NN","Gekeler C","Bayer AS","Peschel A."],"DOI_URL":null}},"set_info":{"accession":"CL0257","name":"Acetyltrans"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":132,"interactions":0,"matches":11427,"pathways":0,"proteins":11396,"proteomes":8231,"sets":1,"structural_models":{"alphafold":7112},"structures":15,"taxa":12407},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":68,"alignment:full":6152},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2hqy","name":"Crystal Structure of Conserved Protein of Unknown Function from Bacteroides thetaiotaomicron VPI-5482"}}}