This entry includes uncharacterised protein YfaA from Escherichia coli (strain K12). This protein has a fold that seems to be a a fusion of membrane permeability and extracellular sensor domains according to DALI pairwise alignment of PDBe:eszA, PDBe:3k8hA and PDBe:4esqA structures [[cite:PUB00152793]]. This suggests that the protein could serve as a signaling device.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Domain_of_unknown_function","extract":"A domain of unknown function (DUF) is a protein domain that has no characterised function. These families have been collected together in the Pfam database using the prefix DUF followed by a number, with examples being DUF2992 and DUF1220. As of 2019, there are almost 4,000 DUF families within the Pfam database representing over 22% of known families. Some DUFs are not named using the nomenclature due to popular usage but are nevertheless DUFs.
","thumbnail":null}],"literature":{"PUB00152793":{"PMID":36419248,"ISBN":null,"volume":"32","issue":"1","year":2023,"title":"DALI shines a light on remote homologs: One hundred discoveries.","URL":null,"raw_pages":"e4519","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Holm L","Laiho A","Toronen P","Salgado M."],"DOI_URL":"https://doi.org/10.1002/pro.4519"}},"set_info":{"accession":"CL0932","name":"TP0453-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":2,"interactions":0,"matches":292,"pathways":0,"proteins":286,"proteomes":286,"sets":1,"structural_models":{"alphafold":152},"structures":0,"taxa":385},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":3,"alignment:full":90},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}